Fibrin



Fibrin (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, i.e. the crystal structure of Fibrin from Petromyzon marinus (1n73).

3D Structures of Fibrin
3h32 – hFIa peptide+ hFI α, β, γ chains – human

2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains

2hlo, 1n86 - hFIa α, β, γ chains + peptide

1n8e - hFIa α, β, γ chains

1n73 - FIa α, β, γ chains + peptide – Sea lamprey

1fzc – hDDFIa+peptide